Surgery for Obesity and Weight-Related Diseases Changes the Inflammatory Profile in Women with Severe Obesity: a Randomized Controlled Clinical Trial.

INTRODUCTION/PURPOSE: Obesity increases significantly every year worldwide. Since 1980, the prevalence of individuals with obesity has practically doubled. Obesity plays an important role in the pathophysiology of diseases that arise from a complex interaction of nutritional, genetic, and metabolic factors, characterizing a chronic inflammatory state. This study aimed to verify the systemic inflammatory response through the analysis of IGF-1, IL-23, and resistin levels and the lipid profile in severely obese women undergoing surgery for obesity and weight-related diseases. MATERIALS AND METHODS: This randomized controlled clinical trial includes female patients clinically diagnosed with severe obesity with an indication for bariatric surgery. RESULTS: In the initial evaluation, no significant difference was observed between the control (CG) and bariatric surgery (BSG) groups. The weight, BMI, systolic and diastolic blood pressures, total cholesterol, LDL, HDL, total non-HDL cholesterol, and glucose in BSG patients showed a significant change after surgery. Pre- and post-surgery levels of resistin, IGF-1, and IL-23 showed a significant difference in the BSG group, but only IL-23 was changed after 6 months in the CG. CONCLUSION: The results of this study confirmed that weight loss induced by surgery for obesity and weight-related diseases improved the lipid profile and reduced the chronic inflammatory status in women with severe obesity.

Clinical and Radiographic Aspects of Patients with Femoroacetabular Impingement Syndrome: Is There Difference between Symptomatic and Asymptomatic Hip?

Objective This paper aims to compare clinical and radiographic features of symptomatic and asymptomatic hips in patients with unilateral femoroacetabular impingement syndrome (FAIS) and to establish a correlation between these findings. Methods This is a retrospective study, based on medical records of patients diagnosed with FAIS between January 2014 and April 2017. The patients were assessed clinically as per the International Hip Outcome Tool 33 (iHOT33) questionnaire, visual analogue pain scale, hip rotation, and hip and knee muscular strength. The radiographic evaluation consisted of measurements of the alpha angle, crossover signal, acetabular retroversion index, ischial spine signal, and posterior wall sign. Results A total of 45 patients were included in the study, with mean time from symptom onset to diagnosis of 28.6 months and mean iHOT33 score was 39.9. The mean medial rotation was 20.5° in symptomatic hip and 27.2° in asymptomatic hip ( p < 0.001). The crossover signal was positive on 68.9% of the symptomatic hips and 55.6% of the asymptomatic hips ( p = 0.03). The mean retroversion index was 0.15 in symptomatic hips and 0.11 in asymptomatic hips ( p = 0.02). There was a positive correlation between the total time of symptoms and medial hip rotation reduction ( p = 0.04) and between body mass index (BMI) and medial hip rotation reduction ( p = 0.02). Conclusion When comparing clinical and radiographic features, we observed reduction of medial rotation and increase of acetabular retroversion index in the symptomatic hip, as well as association between the long symptom time and the high BMI with loss of medial rotation of the hips.

Clinical and Radiographic Aspects of Patients with Femoroacetabular Impingement Syndrome: Is There Difference between Symptomatic and Asymptomatic Hip? / Aspectos clínicos e radiográficos de pacientes com síndrome do impacto femoroacetabular: Há diferença entre quadril sintomático e assintomático?

Abstract Objective This paper aims to compare clinical and radiographic features of symptomatic and asymptomatic hips in patients with unilateral femoroacetabular impingement syndrome (FAIS) and to establish a correlation between these findings. Methods This is a retrospective study, based on medical records of patients diagnosed with FAIS between January 2014 and April 2017. The patients were assessed clinically as per the International Hip Outcome Tool 33 (iHOT33) questionnaire, visual analogue pain scale, hip rotation, and hip and knee muscular strength. The radiographic evaluation consisted of measurements of the alpha angle, crossover signal, acetabular retroversion index, ischial spine signal, and posterior wall sign. Results A total of 45 patients were included in the study, with mean time from symptom onset to diagnosis of 28.6 months and mean iHOT33 score was 39.9. The mean medial rotation was 20.5º in symptomatic hip and 27.2º in asymptomatic hip (p < 0.001). The crossover signal was positive on 68.9% of the symptomatic hips and 55.6% of the asymptomatic hips (p = 0.03). The mean retroversion index was 0.15 in symptomatic hips and 0.11 in asymptomatic hips (p = 0.02). There was a positive correlation between the total time of symptoms and medial hip rotation reduction (p = 0.04) and between body mass index (BMI) and medial hip rotation reduction (p = 0.02). Conclusion When comparing clinical and radiographic features, we observed reduction of medial rotation and increase of acetabular retroversion index in the symptomatic hip, as well as association between the long symptom time and the high BMI with loss of medial rotation of the hips.

Resumo Objetivos Comparar características clínicas e radiográficas entre quadril sintomático e assintomático em pacientes com síndrome do impacto femoroacetabular unilateral e estabelecer correlações entre os achados. Métodos Estudo retrospectivo, que consultou prontuários de pacientes com síndrome do impacto femoroacetabular, entre janeiro de 2014 e abril de 2017. Os pacientes foram avaliados clinicamente pelo questionário International Hip Outcome Tool 33 (iHOT33), escala visual analógica de dor, amplitude de rotação de quadril e força muscular de quadril e joelho. A avaliação radiográfica foi composta por mensurações do ângulo alfa, sinal do cruzamento, índice de retroversão acetabular, sinal da espinha isquiática e sinal da parede posterior do acetábulo. Resultados Foram incluídos no estudo 45 prontuários de pacientes, com tempo médio de sintomas até o diagnóstico de 28,6 meses e pontuação média no iHOT33 de 39,9. O valor médio de rotação medial do quadril sintomático foi de 20,5º e do assintomático 27,2º, com (p < 0,001). A positividade do sinal do cruzamento para quadril sintomático foi de 68,9% e do assintomático 55,6% (p = 0,03). Para índice de retroversão, o valor médio do quadril sintomático foi de 0,15 e do quadril assintomático foi 0,11 (p = 0,02). Encontramos correlação positiva entre o tempo de sintomas e a redução de amplitude de rotação medial de quadril (p = 0,04) e entre o índice de massa corpórea (IMC) e a redução amplitude de rotação medial de quadril (p = 0,02). Conclusão Ao comparar características clínicas e radiográficas, observamos redução de rotação medial e aumento do índice de retroversão acetabular no quadril sintomático, bem como associação entre o longo tempo de sintoma e o IMC elevado com perda de rotação medial dos quadris.

Assessment of body composition, functional capacity and pulmonary function in patients with Chronic Obstructive Pulmonary Disease / Evaluación de la composición corporal, la capacidad funcional y la función pulmonar en pacientes con Enfermedad Pulmonar Obstructiva Crónica / Avaliação da composição corporal, capacidade funcional e função pulmonar em pacientes com Doença Pulmonar Obstrutiva Crônica

Chronic obstructive pulmonary disease (COPD) is related to a low body mass index (BMI), reduced functional capacity and reduced bone density, thus justifying the importance of evaluating all of these parameters in the patients with the disease. This is a cross-sectional study, with sample consisting of 20 patients who performed measurement of body composition by bioelectrical impedance, evaluation of functional capacity by the distance traveled in the Incremental Shuttle Walk Test (ISWT) and assessment of severity of obstruction by spirometry. Significant differences were found between the travelled and scheduled distance in the ISWT (p<0.01), positive correlations between muscle mass and distance walked in ISWT (r=0.54 with p=0.01), with FEV1 (r=0.488 with p=0.02), FEV1 and bone mass (r=0.497 with p=0.02) and distance traveled with FEV1 (r=0,541 with p=0.01). The correlations found in this study, besides confirming the hypothesis that the severity of the obstruction presented by the change in the lung parenchyma in patients with COPD is related to changes in body composition and functional capacity reduction, also highlight the correlation with bone mass...

La enfermedad pulmonar obstructiva crónica (EPOC) está relacionada con un bajo índice de masa corporal (IMC), reducción de la capacidad funcional y reducción de la densidad ósea, justificando así la importancia de evaluar todos estos parámetros en pacientes con la enfermedad. Este es un estudio transversal, con una muestra de 20 pacientes, que se sometieron a la medición de la composición corporal por bioimpedancia, la evaluación de la capacidad funcional por la distancia recorrida en el Incremental Shuttle Walk Test (ISWT) y la evaluación de la gravedad de la obstrucción por la espirometría. Se encontraron diferencias significativas entre la distancia recorrida y prevista del ISWT (p<0,01), correlaciones positivas entre la masa muscular y la distancia en el ISWT (r=0,54 con p=0,01), con FEV1 (r=0,488 con p=0,02 ), FEV1 y la masa ósea (r=0,497 con p=0,02) y la distancia recorrida con el FEV1 (r=0,541 con p=0,01) . Las correlaciones encontradas en este estudio, además de confirmar la hipótesis de que la gravedad de la obstrucción presentada por los cambios en el parénquima pulmonar en pacientes con EPOC se asocia con cambios en la composición corporal y la reducción de la capacidad funcional, evidencian también la correlación con la masa ósea...

A doença pulmonar obstrutiva crônica (DPOC) está relacionada a um baixo índice de massa corporal (IMC), à redução da capacidade funcional e à redução da densidade óssea, justificando assim a importância de se avaliar todos esses parâmetros nos pacientes portadores da doença. Trata-se de um estudo transversal, com amostra composta por 20 pacientes, que realizaram medida de composição corporal por bioimpedância, avaliação da capacidade funcional pela distância percorrida no Incremental Shuttle Walk Test (ISWT) e avaliação da gravidade da obstrução pela espirometria. Foram encontradas diferenças significantes entre a distância percorrida e prevista do ISWT (p<0,01), correlações positivas entre massa muscular e distância percorrida no ISWT (r=0,54 com p=0,01), com VEF1 (r=0,488 com p=0,02), VEF1 e massa óssea (r=0,497 com p=0,02) e distância percorrida com VEF1 (r=0,541 com p=0,01). As correlações encontradas neste estudo, além de confirmarem a hipótese de que a gravidade da obstrução apresentada pela alteração no parênquima pulmonar nos pacientes com DPOC está relacionada com as alterações na composição corporal e com a redução da capacidade funcional, evidenciam também a correlação com a massa óssea...

Home-based pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a randomized clinical trial.

INTRODUCTION: Pulmonary rehabilitation (PR) is a multidisciplinary program of care for patients with chronic obstructive pulmonary disease (COPD) with the goal of improving the functional capacity and quality of life, as well as maintaining the clinical stability of COPD sufferers. However, not all patients are available for such a program despite discomfort with their condition. The aim of this study was to evaluate the effects of a home-based PR (HBPR) program on functional ability, quality of life, and respiratory muscle strength and endurance. PATIENTS AND METHODS: Patients with COPD according to the Global Initiative of Chronic Obstructive Lung Disease were randomized (double-blind) into two groups. One group performed a protocol at home with aerobic and muscle strength exercises and was called the intervention group; the other group received only instructions to perform breathing and stretching exercises, characterizing it as the control group (CG). We assessed the following variables at baseline and 2 months: exercise tolerance (incremental shuttle walk test and upper limb test), respiratory muscle (strength and endurance test), and health-related quality of life (Airways Questionnaire 20). RESULTS: There were no significant changes after the intervention in either of the two groups in exercise tolerance and quality of life. However, the intervention group had improved respiratory endurance compared with the CG, while the CG presented a decrease in the load sustained by the respiratory muscles after the HBPR. CONCLUSION: A program of HBPR with biweekly supervision (although not enough to provide significant improvements in physical capacity or quality of life) played an important role in maintaining the stability of the clinical features of patients with COPD; the patients had no worsening of symptoms during the intervention period according to the daily log.